On a port injected engine (rather than a DI one) you have to get the fuel and air past the inlet valve. As the air is a lot less desne than the fuel it's the engines volumetric efficiency on it's charger air that is the limiting factor (well it is until you get up to methanol buring top fuel dragsters lol!) hence even on a turbo engine, if you can increase the air ingested during each induction stroke you can increase cylinder filling, add more fuel and get more power out. If you are simply chasing max power, rather than idle stability or emissions you need to only inject on an open inlet valve as fuel siting on the valve and evaporating displaces charge air (and actually reduces the valves flow at low lifts). As you increase the rpm of peak power your valve open event duration decreases, so you need increasing injector flow to have a short enough injection event. If you fit big injectors running at low pressures you tend to find that atomisation becomes a
problem, and brake specific fuel consumption plumets (you still get the power pretty much, but use a lot of fuel doing it as most of it sits in the form of liquid or over rich vapour, only to be burn out the tailpipe)
so the best trend is to ise good atomisation injectors runing at high pressure, hence wrc engines run port injected at approx 16bar, and F1 engines run port injected at 50+ bar! (a modern F1 engine is practically a DI with a pencil jet injector shooting past the valve into a controlled arear of the chamber)
For ultra high performance NA engines (8500rpm+) there is a trade off in terms of running remote injectors which give the fuel plenty of time to evaporate and also provide a degree of air charge cooling (which increases charge density, but usually requires injectors 200mm or more upstream of the valve)
I run with std bosch injectors, with std O rings, but beefed up retaining clips (although there is only approx 200N pushing the injectors out of the rail) i do run with a clever fuel injector driver system, that effectively mimics a peak and hold system to over drive the injectors to get them open as fast as possible against the fuel pressure. Injector life i hear you ask?? er, good question, i'm expecting about 1000km before new ones are needed!
hope that helps!